GnRH受體（胞外）抗體（50 ul）-Anti-GnRH Receptor （extracellular)代理/參數/廠家-一抗-艾美捷科技有限公司

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背景資料: Gonadotropin-releasing hormone (GnRH) or Luteinizing hormone releasing hormone (LHRH) is a decapeptide synthesized and released from neurons in the hypothalamus and stimulates the synthesis and release of gonadotropin hormone (or luteinizing hormone) and follicle stimulating hormone from the pituitary gland1. GnRH is expressed as various variants, and most vertebrates express more than one form of GnRH.nGnRH and its variants bind and activate GnRH receptor (GnRHR), a member of the G-protein coupled receptor (GPCR) superfamily. Three forms of the receptor have been identified in vertebrates (types I, II and III). Like all members, GnRHR has seven transmembrane domains and an extracellular N-terminus and an intracellular C-terminal tail. The receptor also has a number of glycosylation sites in its extracellular loops. In addition, the C-terminal tail is unusually short and lacks consensus sites known to undergo post-translational modifications like phosphorylation. In consequence, this affects the receptor’s desensitization and internalization.Expression of GnRHR is detected in the gonadotrope and various tissues like breast, gonads, prostate and uterus.

免疫原: GnRH 受體 (胞外)抗體的免疫原肽段為(C)NNASLEQDQNH。此免疫原序列來源于3-13 位氨基酸殘基，該序列來源于大鼠GnRH 受體 (Accession編號為P30969)。胞外, N端

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