甜菜堿/ GABA轉運蛋白1（BGT-1）抗體（25 ul）-Anti-Betaine/GABA Transporter 1 （BGT-1)代理/參數/廠家-一抗-艾美捷科技有限公司

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背景資料: γ-aminobutyric acid (GABA) transporters (GATs) are essential regulators of the activity in the GABAergic system through their continuous uptake of the neurotransmitter from the synaptic cleft and extrasynaptic space. Four GABA transporters (GAT1, GAT2, GAT3 and BGT1) have been identified. Betaine/GABA transporter (BGT1, SLC6A12) is a member of the Na+- and Cl?-dependent neurotransmitter transporter gene family (SLC6) with a high homology to GAT1 (SLC6A1), GAT2 (SLC6A13) and GAT3 (SLC6A11). They have 12 hydrophobic transmembrane domains (TMDs), a large extracellular loop between TMD3 and 4 with multiple glycosylation sites, and intracellular N- and C-termini.nBGT1 expression may vary among species. In the dog, BGT1 mRNA is primarily detected in the kidney while the levels in the brain and liver are considerably lower. The highest BGT1 mRNA levels in the mouse are in the liver, while the highest levels in man are in the kidney followed by the liver3. BGT-1 is also present in the brain, but appears to be at low levels and mostly in the leptomeninges rather than in brain tissue proper.nHomozygous BGT1-deficient mice have normal development and show seizure susceptibility indistinguishable from that in wild-type mice in a variety of seizure threshold models.

免疫原: Betaine/GABA Transporter 1 (BGT-1)抗體的免疫原肽段為(C)GEMMDQKDKDQVKD。此免疫原序列來源于22- 35 位氨基酸殘基，該序列來源于大鼠Betaine/GABA Transporter 1 (Accession編號為P48056)。胞內, N端

保存建議: 艾美捷為您提供的Betaine/GABA Transporter 1 (BGT-1)抗體(25 ul)為室溫運輸，建議您收到產品后﹣20℃保存。

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