H4 Histamine Receptor couples to Gi/G0 proteins and receptor activation leads to inhibition of adenylate cyclase, mobilisation of calcium from intracellular stores and activation of the mitogen-activated protein kinase (MAPK) cascade. nH4 Histamine Receptor is largely expressed in haemopoietic cells including mast cells, eosinophils, dendritic cells and T lymphocytes. H4 Histamine Receptors modulate eosinophil migration and the selective recruitment of mast cells leading to amplification of histamine-mediated immune responses. In addition, H4 Histamine Receptors are involved in dendritic cell activation and the regulation of T lymphocyte cytokine production.nThese studies indicate that H4 Histamine Receptor is an attractive therapeutic target for the treatment of inflammatory disorders, such as allergy, asthma, chronic pruritus and autoimmune diseases.
應用類型
經驗證，該抗體可應用于IFC、WB等實驗。
免疫原
Human H4 Histamine 受體 (胞外)抗體的免疫原肽段為HTLFEWDFGKEIC。此免疫原序列來源于75-87位氨基酸殘基，該序列來源于人類H4 Histamine 受體 (Accession編號為Q9H3N8)，第二胞外環。
