Recently, several key players of the store operated complex have been identified. Orai1 (also known as CRACM1) acts as the store operated Ca2+ channel (SOC) and STIM1, which acts as the endoplasmic reticulum Ca2+ sensor. The formation of functional channels by Orai1 requires the presence of both Orai1 and STIM1 proteins working as a complex that involves the co-clustering of Orai1 on the plasma membrane with STIM1 on the endoplasmic reticulum. TRPC1, a member of the transient receptor potential family was also suggested to act as a player in the SOC complex7. In T-cells, Ca2+ entry following activation by antigen-receptor engagement occurs solely through CRAC channels where Orai1 constitutes the pore forming subunit.nOrai1 is a plasma membrane protein with four potential transmembrane domains and intracellular N- and C-termini. In addition, two mammalian homologs to Orai1 have been identified; Orai2 and Orai3. All three, Orai1 Orai2 and Orai3, are capable of forming store operated channels with different properties
應用類型
經驗證，該抗體可應用于FC、WB等實驗。
免疫原
Human Orai1 (胞外)-Biotin抗體的免疫原肽段為合成 mapping to an 胞外 sequence位氨基酸殘基，該序列來源于人類Orai1 (Accession編號為Q96D31)。
