The p75NTR receptor is a member of the TNF receptor superfamily. p75NTR, like all the superfamily members is a type I transmembrane protein with tandem cysteine-rich domains in the extracellular portion and a intracellular death domain. p75NTR binds its ligands as a homodimer but can also form heterodimers with other receptors such as TrkA, TrkB, TrkC, Nogo receptor and sortilin. The precise multimeric receptor complex formed between p75NTR and the other receptors will determine the ligand being recognized (see below) and the biological response to its binding.
應用類型
經驗證，該抗體可應用于IC、IFC、IH、IP、LCI、WB等實驗。
免疫原
Human p75NTR(胞外)抗體的免疫原肽段為CEEIPGRWITRSTPPE。此免疫原序列來源于188-203位氨基酸殘基，該序列來源于人類p75NTR (SwissProt Accession編號為P08138)。 胞外, stalk 結構域。
