In general GFLs all signal through a signal through the receptor tyrosine kinase Ret. Their specificity is implemented by different GDNF family receptor a (GFRα), which act as co-receptors. These extracellular proteins are bound to the plasma membrane via a glycosyl phosphatidyl inositol (GPI) anchor. GFRα1-4 are responsible for the binding of GDNF, NRTN, ARTN, and PSPN respectively and the subsequent activation of Ret. Soluble forms of the receptor by the cleavage of a yet unknown phospholipase or protease can be detected. Also alternative spliced forms of the protein can lead to soluble forms of GFRα receptors.In respect to their important role in development, individual knockout of either gdnf, gfra1 or ret gives rise to lethal phenotypes
應用類型
經驗證，該抗體可應用于IC、IH、LCI、WB等實驗應用，也可用于IFC、IP等實驗。
免疫原
GDNF Family 受體 Alpha1 (胞外)抗體的免疫原肽段為CRSAMEALKQKS。此免疫原序列來源于72-83 位氨基酸殘基，該序列來源于大鼠GFRα1 (Accession編號為Q62997)。 胞外 結構域。
來源宿主
兔
反應性
反應性：人、 小鼠、 大鼠
保存建議
艾美捷為您提供的GDNF Family 受體 Alpha1 (胞外)抗體(50 ul)為室溫運輸，建議您收到產品后﹣20℃保存。
