The GDNF family ligands (GFLs) belong to the super family of the TGF-β. They belong to the group of cystine-knot protein and function as homodimers. This family includes glial cell line-derived neurotrophic factor (GDNF), artemin (ARTN), Neurturin (NRTN) and persephin (PSPN).nThese factors are heavily involved in the development and function of the nervous system (both central and peripheral). In particular GDNF has an important role outside the nervous system where it plays a role in kidney morphogenesis.nIn general GFLs all signal through a signal through the receptor tyrosine kinase Ret. Their specificity is implemented by different GDNF family receptor a (GFRα), which act as co-receptors. These extracellular proteins are bound to the plasma membrane via a glycosyl phosphatidyl inositol (GPI) anchor. GFRα1-4 are responsible for the binding of GDNF, NRTN, ARTN, and PSPN respectively and the subsequent activation of Ret. Soluble forms of the receptor by the cleavage of a yet unknown phospholipase or protease can be detected1,3. Also alternative spliced forms of the protein can lead to soluble forms of GFRα receptors
應用類型
經驗證，該抗體可應用于IC、IH、LCI、WB等實驗應用，也可用于IFC、IP等實驗。
免疫原
GDNF Family 受體 Alpha4 (胞外)抗體的免疫原肽段為(C)GSRDG(S)PEEGGPR。此免疫原序列來源于160-172 位氨基酸殘基，該序列來源于大鼠GFRα4 (Accession編號為Q9EPI2)。胞外，N端。
來源宿主
兔
反應性
反應性：小鼠、 大鼠
保存建議
艾美捷為您提供的GDNF Family 受體 Alpha4 (胞外)抗體(50 ul)為室溫運輸，建議您收到產品后﹣20℃保存。
