HCN1抗體（50 ul）-Anti-HCN1代理/參數/廠家-一抗-艾美捷科技有限公司

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背景資料: Hyperpolarization-activated cation currents (Ih) appear in the heart and the brain and have a crucial role in controlling electrical pacemaker activity, contributing to biological processes such as heartbeat, sleep-wake cycle and synaptic plasticitynThe Ih currents are generated by the Hyperpolarization-activated cyclic nucleotide-gated channel family (HCN), which is comprised of four homologous members, HCN1-4.nEach HCN subunit consists of six transmembrane domains (TM), a pore region between TM5-TM6 and a binding domain for cyclic nucleotides (CNBD) in the cytoplasmic C-terminus.The HCN subunits can form functional homomers and can also co-assemble into functionally heteromers.The channels are closely related to each other and share a homology of about 60%. However, their similarity decreases in the cytoplasmic N- and C-termini. The channels HCN1-4 mainly differ from each other in their speed of activation and the extent to which they are modulated by cAMP. HCN1, weakly affected by cAMP, is the fastest channel, followed by HCN2, HCN3 and HCN4. nHCN1 is extensively expressed in the brain, in specific areas like the neocortex, hippocampus, cerebellum and superior colliculus.

免疫原: HCN1抗體的免疫原肽段為(C)KPNSASNSRDDGNSVYPSK。此免疫原序列來源于6-24 位氨基酸殘基，該序列來源于大鼠HCN1(Accession編號為Q9JKB0)。胞內, N端

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