- 中文名稱
sloBeta3（KCNMB3）（胞外）抗體（50 ul）
- 英文名字
- Anti-sloBeta3 （KCNMB3) （extracellular)
- 供應商
- Alomone
- 產品貨號
- ALO-APC-068-50
- 產品報價
- ￥已停產
- 產品說明書
- 點擊查看
- 購買方式
- 銀行轉賬、電匯、支票、現金，在線支付寶及網銀支付，或直接與我們電話聯系400-6800-868。
- 產品新聞
- 背景資料
- Large-conductance, voltage- and Ca2+-activated K+ channels, also known as the BK channels, are widely expressed channels that couple changes in submembrane Ca2+ concentration to the regulation of electrical excitability. BK channels are formed from four α-subunits arising from the Slowpoke (Slo) gene product. In addition, in smooth muscle and cochlea, an accessory β-subunit can regulate BK channel gating profoundly. At present, four β subunits have been cloned in mammals. β Subunits alter the Ca2+ sensitivity and gating kinetics of BK channels, greatly contributing to BK channel diversity. On the other hand, they modify the BK channel pharmacological properties, changing toxin binding and acting as receptors for drugs.n Regulatory β subunits share a putative membrane topology, with two transmembrane segments connected by a 120- residue extracellular loop and with NH2 and COOH terminals oriented toward the cytoplasm4. Each β subunit has a tissue-specific expression and modulates channel function uniquely which provides a major mechanism for diverse BK channel phenotypes in various tissues.n β3 is highly expressed in kidney, heart, and brain5. The β3 gene (KCNMB3) associates with Slo1 α subunits and regulate BK channel function. In humans, the β3 gene contains four N-terminal alternative exons that produce four functionally distinct β3 subunits, β3a-d. Three variants, β3a-c, exhibit kinetically distinct inactivation behaviors6. A mutation in the β3 gene is linked to idiopathic epilepsy
- 應用類型
- 經驗證，該抗體可應用于WB等實驗應用，也可用于IC、IFC、IH、IP、LCI等實驗。
- 免疫原
- sloBeta3 (KCNMB3) (胞外)抗體的免疫原肽段為(C)HYDEEAIRTNPK。此免疫原序列來源于134- 145 位氨基酸殘基，該序列來源于大鼠Sloβ3 (Accession編號為A7VL23)。 胞外 環。
- 來源宿主
- 兔
- 反應性
- 反應性：小鼠、 大鼠
- 保存建議
- 艾美捷為您提供的sloBeta3 (KCNMB3) (胞外)抗體(50 ul)為室溫運輸，建議您收到產品后﹣20℃保存。
- 其他
- Alomone成立于1989年,已經成為全世界科學家信賴的最全面的離子通道研究工具供應商。產品覆蓋離子通道、G蛋白耦聯受體和神經信號研究所需的一抗、小分子、蛋白質和多肽等。所有Alomone產品均進行了生物實驗驗證，以凍干粉形式提供，可確保產品生物活性和保質期。Alomone可提供多種包裝規格，靈活方便。作為Alomone Labs在中國的區域總代理，艾美捷科技有限公司將為中國客戶提供最全面的Alomone Labs產品以及客戶訂制化服務。
- 注意
-
該頁面的中文產品信息的翻譯，僅供參考。準確的產品信息請以廠家的英文說明書為準。下單前，請瀏覽說明書確認。
-
