The KV11.1 (HERG) channel is a member of the ether-a-go-go (EAG) subfamily of voltage-dependent K+ channels that includes the related proteins KV11.2 and KV11.3 (erg2 and erg3). KV11.1 possess the signature structure of the voltage-dependent K+ channels: six membrane-spanning domains and intracellular N and C termini.nThe KV11.1 current is characterized by strong inward rectification with slow activation and very rapid inactivation kinetics. The channel is expressed in the brain and heart (where it underlies the IKr current) and has a central role in mediating repolarization of action potentials.
應用類型
經驗證，該抗體可應用于FC
免疫原
KV11.1 (胞外)-FITC抗體的免疫原肽段為AFLLKETEEGPPATEC 對應于430-445位氨基酸殘基，該序列來源于人類KV11。1 (HERG) (Accession編號為Q12809 )。 胞外, between S1和S2 結構域s。
