Shank family proteins (shank1, shank2 and shank3) are neuronal scaffold proteins that organize a cytoskeleton-associated signaling complex at the postsynaptic density (PSD) of nearly all excitatory glutamatergic synapses in the mammalian brain.Shank1 mRNA, being synthesized in dendritic spine, can locally control the spine morphology. The Shank1 gene is located on chromosome 19q13.33 and contains 23 exons and two alternative promoters leading to two distinct isoforms. Shank1 is highly expressed in the cortex and hippocampus.Recent studies indicate that Shank1 is a causative gene for idiopathic autism spectrum disorders (ASD)1. In addition it was found that Shank1 has a role in working memory deficits in schizophrenia6. Shank1 knock-out mice display increased anxiety and decreased vocal communication
應用類型
經驗證，該抗體可應用于WB等實驗應用，也可用于IC、IH、IP等實驗。
免疫原
Shank1抗體的免疫原肽段為(C)RSQEGRQESRSDKAK。此免疫原序列來源于614- 628 位氨基酸殘基，該序列來源于大鼠Shank1 (Accession編號為Q9WV48)。胞內, between the SH3和PDZ 結構域s。
