The majority of Na+ channels in the mammalian heart are Tetrodotoxin (TTX) insensitive Nav1.5. nThe putative structure of NaV1.5 consists of four homologous domain (I-IV), each containing six transmembrane segments (S1-S6). Mutations in the C-terminus of NaV1.5 were described in connection to Long QT syndrome and Brugada syndrome.Recent data have demonstrated selective expression of NaV1.5 in the mouse central nervous system and implicated a role for NaV1.5 in the physiology of the central nervous system
應用類型
經驗證，該抗體可應用于IC、IFC、IH、WB等實驗應用，也可用于 IP等實驗。
免疫原
Human NaV1.5抗體的免疫原肽段為含特定氨基酸殘基的GST融合蛋白：1978-2016位氨基酸殘基，該序列來源于人類Nav1。5 (Accession編號為# Q14524), (MW: 33 kDa。)。胞內, C端。
