The existence of resting K+ conductance has been known for some time. Only recently has the Nalcn (sodium leak channel non-selective protein) has been found responsible for the resting Na+ conductance.Nalcn is a member of the NaV and CaV channels family which have four homologous repeats of six transmembrane domains. One structural difference is that Nalcn is less positively charged in the voltage sensing segment. The protein forms voltage-independent non-inactivating channel which is permeable to Na+, K+ and Ca2+ ion.nEvidence suggests that Nalcn is a non-redundant and thus essential channel since knock-out mice display disrupted respiratory rhythm and die with 24 hours of birth. In addition, isolated neurons from these mice have decreased excitability.The channel is extensively expressed in the central nervous system1, heart, pituitary and adrenal glands and pancreatic islet cell.In pancreatic islets, Nalcn is activated by acetylcholine via its physical association with M3 muscarinic receptor, and potentiates insulin secretion induced by glucose uptake
應用類型
經驗證，該抗體可應用于IC、IH、LCI、WB等實驗應用，也可用于IFC、IP等實驗。
免疫原
Sodium Leak Channel Non-Selective Protein (Nalcn) (胞外)抗體的免疫原肽段為(C)SMMFESPFRRVMH。此免疫原序列來源于902-914 位氨基酸殘基，該序列來源于大鼠Sodium leak channel non-selective protein (Accession編號為Q6Q760)。 胞外, S1-S2 結構域 III。
來源宿主
兔
反應性
反應性：人、 小鼠、 大鼠
保存建議
艾美捷為您提供的Sodium Leak Channel Non-Selective Protein (Nalcn) (胞外)抗體(50 ul)為室溫運輸，建議您收到產品后﹣20℃保存。
