NaVBeta4（胞外）抗體（50 ul）-Anti-NaVBeta4 （extracellular)代理/參數/廠家-一抗-艾美捷科技有限公司

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背景資料: Voltage-gated sodium channels (NaV) are essential for the generation of action potentials and for cell excitability. NaV channels are activated in response to depolarization and selectively allow flow of Na+ ions. To date, nine NaV α subunits have been cloned and named Nav1.1-Nav1.. The Nav channels are classified into two groups according to their sensitivity to Tetrodotoxin (TTX): TTX-sensitive (NaV1.1, NaV1.2, NaV1.3, NaV1.4, NaV1.6 and NaV1.7 and TTX-resistant (NaV1.5, NaV1.8 and NaV1.9) . Mammalian Na+ channels are heterotrimers, composed of a central, pore-forming α subunit and two auxiliary β subunits. The expression of the α subunit isoform is developmentally regulated and tissue specific. Na+ channels in the adult central nervous system and heart contain β1 through β4 subunits, whereas Na+ channels in adult skeletal muscle have only the β1 subunit.nNavβ4 has been associated with Long QT syndrome8 and with Huntington's disease, showing a distinct down regulation of NaVβ4 in the presymptomatic stage of HD mice, whereas other voltage-gated ion channel subunits were later decreased

免疫原: NaVBeta4 (胞外)抗體的免疫原肽段為(C)KNDKSDPKVRVKDD。此免疫原序列來源于85-98 位氨基酸殘基，該序列來源于大鼠NaVβ4 (Accession編號為Q7M730)。胞外，N端。

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