CyPPA is an activator of small conductance Ca2+-activated K+ channels that displays selectivity for SK2 and SK3 channels (EC50 values are 5.6 and 14 μM for SK3 and SK2 respectively and efficacy is 90% and 71% for hSK3 and hSK2, respectively). CyPPA displays no activity at SK1 and IK (KCa3.1)channels.
產品描述
A Selective and Potent Opener of KCa2.2 and KCa2.3 Channels and a Blocker of TRPM7 Channel
產品形式
Ca2+-activated potassium channels (KCa) are a group of 6/7-TM ion channels that selectively transport K+ ions across biological membranes. They are broadly classified into three subtypes: SK, IK and BK channels (small, intermediate and big conductance).nnSmall-conductance Ca2+-activated K+ channels (SK channels) underlie the medium duration after hyperpolarization that follows single or trains of action potentials in many types of neurons. This family is composed of KCa2.1 (SK1), -2.2 (SK2), and -2.3 (SK3) isoforms, which are expressed differentially within the central nervous system.
