歐米茄芋螺毒素MVIIC（1毫克）-Omega-Conotoxin MVIIC代理/參數/廠家-生化試劑-艾美捷科技有限公司

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背景資料: ω-Conotoxin MVIIC, blocks CaV2.1 (α1A, P/Q-type) and Cav2.2 (α1B, N-type) channels. The toxin binds with high affinity to Cav2.1 and with lower affinity to Cav2.2 in rabbit brain. However, the block by ω-Conotoxin-MVIIC, of N-type channels in DRG neurons developed much faster than the block of P-type currents in Purkinje cells. The effect of the toxin is modulated by voltage (i.e. it is more potent for inactivated channels). In addition this toxin was reported to block nicotinic receptors (transiently expressed in Xenopus oocytes) with IC50 of 1.3 μM. It was also shown to inhibit K+-induced 3H-GABA release in hippocampus in vivo. This effect was with high affinity (50% block, 200 nM). The toxin was used to inhibit synaptic transmission in several peripheral preparations.

產品形式: ω-Conotoxin MVIIC, blocks CaV2.1 (α1A, P/Q-type) and Cav2.2 (α1B, N-type) channels. The toxin binds with high affinity to Cav2.1 and with lower affinity to Cav2.2 in rabbit brain. However, the block by ω-Conotoxin-MVIIC, of N-type channels in DRG neurons developed much faster than the block of P-type currents in Purkinje cells. The effect of the toxin is modulated by voltage (i.e. it is more potent for inactivated channels). In addition this toxin was reported to block nicotinic receptors (transiently expressed in Xenopus oocytes) with IC50 of 1.3 μM. It was also shown to inhibit K+-induced 3H-GABA release in hippocampus in vivo. This effect was with high affinity (50% block, 200 nM). The toxin was used to inhibit synaptic transmission in several peripheral preparations.

保存建議: 艾美捷為您提供的Alonmone Labs原裝進口的Omega-Conotoxin MVIIC (1 mg)產品可室溫運輸，建議您在收到產品后將其置于合適的溫度下保存。

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