卡維地洛（250毫克）-Carvedilol代理/參數/廠家-生化試劑-艾美捷科技有限公司

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背景資料: Carvedilol is a potent nonselective β1-, β2-, and α1- adrenoceptor antagonist drug with an IC50 value of 3.8 μM. Carvedilol is also vasodilator with antioxidant, anti-inflammatory, antifibrotic and antiproliferative effects. It has “atypical” effects on β-receptors mediated by an interaction with G proteins that leads to downregulation of receptors in model systems. Experimental models demonstrate that Carvedilol blocks α1-, β1-, and β2-adrenergic receptors without exhibiting high levels of inverse agonist activity. The lack of inverse agonist activity and intrinsic sympathomimetic activity (ISA) reduces the side-effects and makes the compound better tolerated than the older β-blockers. The pharmacologic effects of carvedilol are related to the inhibition of multiple neurohormonal pathways. Additional studies indicate that some of the efficacy of carvedilol may be associated with its effects on levels of inflammatory cytokines. Carvedilol also blocks KV1. channels independently of its action on adrenoceptors5, as well as Kir2.3 channels.

產品描述: A Blocker of KV1.5 and Kir2.3 Channels and an Antagonist of Adrenoceptors

產品形式: Carvedilol is a potent nonselective β1-, β2-, and α1- adrenoceptor antagonist drug with an IC50 value of 3.8 μM. Carvedilol is also vasodilator with antioxidant, anti-inflammatory, antifibrotic and antiproliferative effects. It has “atypical” effects on β-receptors mediated by an interaction with G proteins that leads to downregulation of receptors in model systems. Experimental models demonstrate that Carvedilol blocks α1-, β1-, and β2-adrenergic receptors without exhibiting high levels of inverse agonist activity. The lack of inverse agonist activity and intrinsic sympathomimetic activity (ISA) reduces the side-effects and makes the compound better tolerated than the older β-blockers. The pharmacologic effects of carvedilol are related to the inhibition of multiple neurohormonal pathways. Additional studies indicate that some of the efficacy of carvedilol may be associated with its effects on levels of inflammatory cytokines. Carvedilol also blocks KV1. channels independently of its action on adrenoceptors5, as well as Kir2.3 channels.

保存建議: 艾美捷為您提供的Alonmone Labs原裝進口的Carvedilol (250 mg)產品可室溫運輸，建議您在收到產品后將其置于合適的溫度下保存。

其他: Alomone成立于1989年,已經成為全世界科學家信賴的最全面的離子通道研究工具供應商。產品覆蓋離子通道、G蛋白耦聯受體和神經信號研究所需的一抗、小分子、蛋白質和多肽等。所有Alomone產品均進行了生物實驗驗證，以凍干粉形式提供，可確保產品生物活性和保質期。Alomone可提供多種包裝規格，靈活方便。作為Alomone Labs在中國的區域總代理，艾美捷科技有限公司將為中國客戶提供最全面的Alomone Labs產品以及客戶訂制化服務。