中文名稱

E-4031（10毫克）

英文名字

E-4031

供應商

Alomone

產品貨號

ALO-E-500-10

產品報價

￥已停產

產品說明書

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購買方式

銀行轉賬、電匯、支票、現金，在線支付寶及網銀支付，或直接與我們電話聯系400-6800-868

產品新聞

背景資料

E-4031 is a methanesulfonanilide class III antiarrhythmic agent known to inhibit KV11.1 (hERG) channels. Sub-micromolar concentration of E-4031, selectively blocks Kv11.1 channels, either in heterologous systems,cardiac cells and cardiac preparations. E-4031 was shown to rescue the functional expression of mutated (LQ2) KV11.1 channels in HEK cells. E-4031 (40 μM) treatment also prevented FAK phosphorylation and Rac1 activity (only in HEK cells expressing the KV11.1 subunit). In rat carotid chemoreceptor cells, 1 μM E-4031 inhibited the KV current, to a larger extent in postnatal cells, establishing the developmental disappearance of KV11.1 channels and their contribution to the response to hypoxia. E-4031 (1 μM) accelerated myoblast fusion, probably by blocking KV11.1 channels that leads to depolarization.

產品描述

A Blocker of KV11.1 (hERG) K+ Channels

產品形式

E-4031 is a methanesulfonanilide class III antiarrhythmic agent known to inhibit KV11.1 (hERG) channels. Sub-micromolar concentration of E-4031, selectively blocks Kv11.1 channels, either in heterologous systems,cardiac cells and cardiac preparations. E-4031 was shown to rescue the functional expression of mutated (LQ2) KV11.1 channels in HEK cells. E-4031 (40 μM) treatment also prevented FAK phosphorylation and Rac1 activity (only in HEK cells expressing the KV11.1 subunit). In rat carotid chemoreceptor cells, 1 μM E-4031 inhibited the KV current, to a larger extent in postnatal cells, establishing the developmental disappearance of KV11.1 channels and their contribution to the response to hypoxia. E-4031 (1 μM) accelerated myoblast fusion, probably by blocking KV11.1 channels that leads to depolarization.

保存建議

艾美捷為您提供的Alonmone Labs原裝進口的E-4031 (10 mg)產品可室溫運輸，建議您在收到產品后將其置于合適的溫度下保存。

其他

Alomone成立于1989年,已經成為全世界科學家信賴的最全面的離子通道研究工具供應商。產品覆蓋離子通道、G蛋白耦聯受體和神經信號研究所需的一抗、小分子、蛋白質和多肽等。所有Alomone產品均進行了生物實驗驗證，以凍干粉形式提供，可確保產品生物活性和保質期。Alomone可提供多種包裝規格，靈活方便。作為Alomone Labs在中國的區域總代理，艾美捷科技有限公司將為中國客戶提供最全面的Alomone Labs產品以及客戶訂制化服務。

注意

該頁面的中文產品信息的翻譯，僅供參考。準確的產品信息請以廠家的英文說明書為準。下單前，請瀏覽說明書確認。

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