中文名稱

艾芬地爾（+）-酒石酸鹽（半酒石酸鹽）（25毫克）

英文名字

Ifenprodil (+)-tartrate salt (hemitartrate salt)

供應商

Alomone

產品貨號

ALO-I-105-25

產品報價

￥已停產

產品說明書

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購買方式

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產品新聞

背景資料

fenprodil is an atypical, selective, noncompetitive, voltage-independent partial antagonist of N-methyl-D-aspartate (NMDA) receptors. Its maximal inhibition is approximately at 90%. Ifenprodil inhibits GluN2B-containing receptors with high affinity and is more potent for GluN1/GluN2B receptors. Ifenprodil action is pH-dependent and may cause an increase in tonic proton inhibition. There is evidence that ifenprodil binds outside the ion channel pore to the large interlobe cleft of the NR2B N-terminal domain and acts at a discrete sites with an allosteric interaction. Mutations at distinct residues in the R domain of NR1 and NR2B greatly influence ifenprodil inhibition, thus it seems that this region may form part of the ifenprodil binding site. IC50 values of ifenprodil are 0.15 μM for NR2B subunit, 39 μM for NR2A, 29 μM for NR2C and 76 μM for NR2D.

產品描述

An Antagonist of NMDA Receptors

產品形式

fenprodil is an atypical, selective, noncompetitive, voltage-independent partial antagonist of N-methyl-D-aspartate (NMDA) receptors. Its maximal inhibition is approximately at 90%. Ifenprodil inhibits GluN2B-containing receptors with high affinity and is more potent for GluN1/GluN2B receptors. Ifenprodil action is pH-dependent and may cause an increase in tonic proton inhibition. There is evidence that ifenprodil binds outside the ion channel pore to the large interlobe cleft of the NR2B N-terminal domain and acts at a discrete sites with an allosteric interaction. Mutations at distinct residues in the R domain of NR1 and NR2B greatly influence ifenprodil inhibition, thus it seems that this region may form part of the ifenprodil binding site. IC50 values of ifenprodil are 0.15 μM for NR2B subunit, 39 μM for NR2A, 29 μM for NR2C and 76 μM for NR2D.

保存建議

艾美捷為您提供的Alonmone Labs原裝進口的Ifenprodil (+)-tartrate salt (hemitartrate salt) (25 mg)產品可室溫運輸，建議您在收到產品后將其置于合適的溫度下保存。

其他

Alomone成立于1989年,已經成為全世界科學家信賴的最全面的離子通道研究工具供應商。產品覆蓋離子通道、G蛋白耦聯受體和神經信號研究所需的一抗、小分子、蛋白質和多肽等。所有Alomone產品均進行了生物實驗驗證，以凍干粉形式提供，可確保產品生物活性和保質期。Alomone可提供多種包裝規格，靈活方便。作為Alomone Labs在中國的區域總代理，艾美捷科技有限公司將為中國客戶提供最全面的Alomone Labs產品以及客戶訂制化服務。

注意

該頁面的中文產品信息的翻譯，僅供參考。準確的產品信息請以廠家的英文說明書為準。下單前，請瀏覽說明書確認。

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