Isopimaric acid (originally isolated from terpenoids) was found to be a potent opener of KCa1.1 (large conductance Ca2+ activated K+-(BK) channels. 1 μM Isopimaric acid doubled the current carried via KCa1.1 channels and this effect increased dose dependently. In analogy to the effects of pimaric acid, isopimaric acid may increase the open probability of single KCa1.1 channels by shifting both its voltage and Ca2+ dependence to more hyperpolarized voltages. KCa1.1 channels that were activated by Isopimaric acid retain their Charybdotoxin sensitivity.
產品描述
A Novel Opener of KCa1.1 Channels
產品形式
Isopimaric acid (originally isolated from terpenoids) was found to be a potent opener of KCa1.1 (large conductance Ca2+ activated K+-(BK) channels. 1 μM Isopimaric acid doubled the current carried via KCa1.1 channels and this effect increased dose dependently. In analogy to the effects of pimaric acid, isopimaric acid may increase the open probability of single KCa1.1 channels by shifting both its voltage and Ca2+ dependence to more hyperpolarized voltages. KCa1.1 channels that were activated by Isopimaric acid retain their Charybdotoxin sensitivity.
保存建議
艾美捷為您提供的Alonmone Labs原裝進口的Isopimaric Acid (5 x 1 mg)產品可室溫運輸，建議您在收到產品后將其置于合適的溫度下保存。
