中文名稱

PU02（5毫克）

英文名字

PU02

供應商

Alomone

產品貨號

ALO-P-165-5

產品報價

￥已停產

產品說明書

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購買方式

銀行轉賬、電匯、支票、現金，在線支付寶及網銀支付，或直接與我們電話聯系400-6800-868

產品新聞

背景資料

PU02 is a synthetic, potent and selective negative allosteric modulator of the 5-HT3 receptor. PU02 has an effective concentration of 0.1-10 μM and an IC50 of approximately 1μM. PU02 acts through a transmembrane site situated between two subunits. The Ser248, Leu288, Ile290, Thr294, and Gly306 residues are identified as important molecular determinants of PU02 activity. It is suggested that the naphthalene group of PU02 docks into the hydrophobic cavity formed by these molecular determinants. Specific mutations of Ser248, Thr294, and Gly306 convert PU02 into a complex modulator, promoting and inhibiting 5-HT-evoked signaling through these mutated sites at low and high concentrations, respectively. The PU02 binding site in the 5-HT3 receptor corresponds to allosteric sites in other anionic Cys-loop receptors. The dramatic changes in the functional properties of PU02 induced by subtle changes in its binding site exhibit that delicate structural can alternate between allosteric inhibition and potentiation of 5-HT and other Cys-loop receptors.

產品描述

A Negative Allosteric Modulator of 5-HT3

產品形式

Serotonin (5-hydroxytryptamine, 5-HT) is a monoamine neurotransmitter synthesized from the amino acid Tryptophan by the enzyme tryptophan-decarboxylase. The 5-HT3 channel is a ligand gated ion channel receptor of the cys-loop channel family. It is a pentamer with five subunits surrounding a central channel.

保存建議

艾美捷為您提供的Alonmone Labs原裝進口的PU02 (5 mg)產品可室溫運輸，建議您在收到產品后將其置于合適的溫度下保存。

其他

Alomone成立于1989年,已經成為全世界科學家信賴的最全面的離子通道研究工具供應商。產品覆蓋離子通道、G蛋白耦聯受體和神經信號研究所需的一抗、小分子、蛋白質和多肽等。所有Alomone產品均進行了生物實驗驗證，以凍干粉形式提供，可確保產品生物活性和保質期。Alomone可提供多種包裝規格，靈活方便。作為Alomone Labs在中國的區域總代理，艾美捷科技有限公司將為中國客戶提供最全面的Alomone Labs產品以及客戶訂制化服務。

注意

該頁面的中文產品信息的翻譯，僅供參考。準確的產品信息請以廠家的英文說明書為準。下單前，請瀏覽說明書確認。

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