Native Aa1 was originally isolated from Androctonus australis scorpion venom. Aa1 blocks Shaker B channels expressed in Xenopus oocytes with IC50=4.5 μM.In addition, the Aa1 toxin was shown to block the fast (A-type) K+ current in cerebellum granular cells (IC 50 =134 nM, or Kd = 150 nM). In both cases the block is non voltage dependent and does not affect kinetic parameters of the K+ currents.
產品描述
A Novel Blocker of Shaker-B and IA K+ Channels
產品形式
Native Aa1 was originally isolated from Androctonus australis scorpion venom. Aa1 blocks Shaker B channels expressed in Xenopus oocytes with IC50=4.5 μM.In addition, the Aa1 toxin was shown to block the fast (A-type) K+ current in cerebellum granular cells (IC 50 =134 nM, or Kd = 150 nM). In both cases the block is non voltage dependent and does not affect kinetic parameters of the K+ currents.