中文名稱

廣西毒素-1E（50 ug）

英文名字

Guangxitoxin-1E

供應商

Alomone

產品貨號

ALO-STG-200-50

產品報價

￥已停產

產品說明書

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購買方式

銀行轉賬、電匯、支票、現金，在線支付寶及網銀支付，或直接與我們電話聯系400-6800-868

產品新聞

背景資料

Guangxitoxin-1E is a 36 amino acid peptidyl toxin isolated from the Chilobrachys jingzhao (Chinese earth tiger) tarantula venom and belongs to the huwentoxin-1 family. Guangxitoxin-1E is a gating modifier of Kv2.1 (KCNB1, IC50 of 1 nM), Kv2.2 (KCNB2, IC50 of 3 nM) and Kv4.3 (KCND3, IC50 of 50 nM) channels. In pancreatic b cells, it enhances glucose-stimulated insulin secretion by broadening the cell action potential and enhancing calcium oscillations. The physiological modulation of Kv2.1 channels during glucose-induced insulin secretion is MgATP-mediated3,4. No significant effect was found on Kv1.2 (KCNA2), Kv1.3 (KCNA3), Kv1.5 (KCNA5), Kv3.2 (KCNC2), Cav1.2 (CACNA1C), Cav2.2 (CACNA1B), Nav1.5 (SCN5A), Nav1.7 (SCN9A) or Nav1.8 (SCN10A) channels.

產品描述

A Potent Gating Modifier of KV2.1, KV2.2 and KV4.3 K+ Channels

產品形式

Guangxitoxin-1E is a 36 amino acid peptidyl toxin isolated from the Chilobrachys jingzhao (Chinese earth tiger) tarantula venom and belongs to the huwentoxin-1 family. Guangxitoxin-1E is a gating modifier of Kv2.1 (KCNB1, IC50 of 1 nM), Kv2.2 (KCNB2, IC50 of 3 nM) and Kv4.3 (KCND3, IC50 of 50 nM) channels. In pancreatic b cells, it enhances glucose-stimulated insulin secretion by broadening the cell action potential and enhancing calcium oscillations. The physiological modulation of Kv2.1 channels during glucose-induced insulin secretion is MgATP-mediated3,4. No significant effect was found on Kv1.2 (KCNA2), Kv1.3 (KCNA3), Kv1.5 (KCNA5), Kv3.2 (KCNC2), Cav1.2 (CACNA1C), Cav2.2 (CACNA1B), Nav1.5 (SCN5A), Nav1.7 (SCN9A) or Nav1.8 (SCN10A) channels.

保存建議

艾美捷為您提供的Alonmone Labs原裝進口的Guangxitoxin-1E (50 μg)產品可室溫運輸，建議您在收到產品后將其置于合適的溫度下保存。

其他

Alomone成立于1989年,已經成為全世界科學家信賴的最全面的離子通道研究工具供應商。產品覆蓋離子通道、G蛋白耦聯受體和神經信號研究所需的一抗、小分子、蛋白質和多肽等。所有Alomone產品均進行了生物實驗驗證，以凍干粉形式提供，可確保產品生物活性和保質期。Alomone可提供多種包裝規格，靈活方便。作為Alomone Labs在中國的區域總代理，艾美捷科技有限公司將為中國客戶提供最全面的Alomone Labs產品以及客戶訂制化服務。

注意

該頁面的中文產品信息的翻譯，僅供參考。準確的產品信息請以廠家的英文說明書為準。下單前，請瀏覽說明書確認。

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