TRAM 34 is a potent and selective KCa3.1 channel inhibitor; 50 nM blocks KCa3.1 channel expressed in COS-7 cells by over 50%. As such, it is a powerful pharmacological tool that enables the determination of the roles played by KCa3.1 channels in different physiological systems, ranging from activation of T lymphocytes to migration of endothelial cells.
產品描述
A Selective and Potent Blocker of KCa3.1 Channels
產品形式
KCa3.1 (SK4, intermediate conductance Ca2+ activated K+) is part of the Ca2+ activated K+ channel family that share the characteristic of being activated by intracellular Ca2+. The channel has an intermediate conductance, is voltage insensitive and is activated by Ca2+ in the submicromolar range. The channel has a similar topology to that of KV channels, that is six transmembrane domains and intracellular N- and C-termini. KCa3.1 is widely expressed in epithelial, endothelial cells and cells of hematopoietic origin. In erythrocytes (red blood cells) it has been identified as the molecular correlate of the so-called Gardos channel.
