PRT4165產品是PRT4165 is a potent inhibitor of PRC1 (polycomb-repressive complex 1)-mediated histone H2A ubiquitylation?in vivo?and?in vitro. PRT4165 inhibits the?in vitro?histone H2A E3 ubiquitin ligase activity of PRC1 components RING1, RNF2, and a BMI1/RNF2 complex. PRT4165 also inhibits DNA double-strand breaks induced ubiquitylation of histone H2AX. In addition, it prevents Bmi1/Ring1A-mediated ubiquitination and drug-induced degradation of topoisomerase 2α?(Top2α).