KU-0060648產品是KU-0060648 is a potent and selective inhibitor of DNA-dependent protein kinase (DNA-PK), (IC?? = 8.6 nM). Displays 20-1000 fold selectivity for DNA-PK over other PIKKs and a panel of 60 kinases. ?Inhibits proliferation of MCF7 cells?in vitro?and delays growth of MCF7 xenografts in mice. Also enhances CRISPR-Cas9-mediated homology-directed repair (HDR) efficiency, and attenuates nonhomologous end-joining (NHEJ).