特里亞平產品是3-AP is a ribonucleotide reductase inhibitor and iron chelator with antitumor activity.?At 5 μM it can enhance DU145, U251, and PSN1 tumor cell radiosensitivity?in vitro, inhibiting DNA synthesis and repair.?It destroys the tyrosine free radical in the R2/p53R2 subunits of ribonucleotide reductase by forming a redox active complex with iron, thus producing reactive oxygen species. In addition, 3-AP has been shown to activate an endoplasmic reticulum stress pathway, leading to the unfolded protein response and apoptosis.
