EPZ015866(GSK591)產品是EPZ015866 (GSK591) is a potent selective inhibitor of the arginine methyltransferase PRMT5/MEP50 complex thus stopping the methylation of histone H4 with IC?? of 11 nM. It also maintains superior selectivity against other panels of methyl transferases inhibiting the symmetric arginine methylation of SmD3 with EC?? of 56 nM.