恩替替尼產品是Entrectinib is an inhibitor of TrkA (IC???= 1.7 nM), TrkB (IC???= 0.1 nM), and TrkC (IC???= 0.1 nM), as well as C-ros oncogene 1 (ROS1; IC???= 0.2 nM) and anaplastic lymphoma kinase (ALK; IC???= 1.6 nM). Entrectinib blocks proliferation of ALK-dependent cell lines, including those with L1196M or C1156Y resistance mutations, and inhibits ALK‐dependent signaling