長春新堿產品是Fevipiprant is a prostaglandin D2?(PGD2) receptor antagonist with a Kd?value of 1.14 nM for CRTH2/DP2.?It has been shown to inhibit PGD2-stimulated human eosinophil shape change in whole blood assays (IC???= 0.44 nM) and to inhibit PGD2-induced cytokine release in human Th2 cells (IC??s = 2.56 and 1.4 nM for IL-5 and IL-13, respectively).?This compound has undergone testing in a phase II clinical study in uncontrolled allergic asthma.