培美曲塞產品是Pemetrexed is a high affinity dihydrofolate reductase (DHFR) inhibitor (Ki?= 7 nM). Also inhibits thymidylate synthase, AICART and glycinamide ribonucleotide formyltransferase (Ki?values are 109 nM, and 3.5 μM and 9.3 μM, respectively). Inhibits proliferation of cancer cell lines?in vitro.