塞拉貝西布產品是Serabelisib is a potent inhibitor of phosphoinositide 3-kinase α (PI3Kα) that is selective for p110α?in vitro?(IC???= 15 nM for PI3Kα?vs.?>1 μM for other isoforms, as well as for mTOR).?MLN1117 inhibits AKT phosphorylation and growth in PIK3CA mutant breast cancer cells with IC?? values around 2 μM, yet has no effect on cells lacking PTEN.