胡椒堿產品是Piperine?is the primary pungent alkaloid isolated from the fruit of black peppercorns.?It displays a variety of therapeutic activities such as anti-oxidant, anti-inflammatory, immunomodulatory, anti-asthmatic, anti-convulsant, anti-mutagenic, antimycobacterial, anti-amoebic, and anti-cancer activities.?Piperine affects cytochrome P450 (CYP) isoforms, inhibiting CYP3A species (Ki?~ 5 μM) and increasing expression of CYP1A and CYP2B in liver.?It also has a biphasic effect on P-glycoprotein activity.
