PF-670462產品是PF-670462 is a potent and selective casein kinase 1ε?(CK1ε) and CK1δ?inhibitor (IC???values are 7.7 and 14 nM respectively) that displays > 30-fold selectivity over 42 other kinases. Inhibits PER protein nuclear translocation (EC???= 290 nM) causing phase shifts in circadian rhythms and attenuates methamphetamine-stimulated locomotion?in vivo.