TC-E 5002產品是TC-E 5002 is an inhibitor of the histone lysine demethylase (KDM) subfamily KDM2/7. It potently inhibits KDM2A, KDM7A and KDM7B with an IC?? of 6.8 μM, 0.2 μM and 1.2 μM respectively. It inhibits the growth of KYSE150 and HeLa cells with GI?? values of 16 μM and 40 μM respectively and arrests cells in the G0/G1 phase of the cell cycle. It inhibits demethylation of H3K27me2 at similar concentrations.