- 中文名稱
Pan DiMethyl-lysine polyclonal antibody
- 英文名字
- Pan DiMethyl-lysine polyclonal antibody
- 供應商
- Bioworld
- 產品貨號
- BS74121
- 產品報價
- ￥詢價/50ul
- 產品說明書
- 點擊查看
- 購買方式
- 銀行轉賬、電匯、支票、現金，在線支付寶及網銀支付，或直接與我們電話聯系400-6800-868
- 產品新聞
- 背景資料
- Methylation is a major post-translational modification (PTM) generated by methyltransferase on target proteins, protein methylation plays important regulatory roles in gene expression, protein activity and stability, and signal transduction. Methylation can occur on specific lysine or arginine residues localized within regulatory domains in both histone and nonhistone proteins, thereby allowing distinguished properties of the targeted protein. Lysine can be methylated to different degrees, including mono-, di-, or trimethylation, which reflects its functional diversity and regulatory complexity compared to other PTMs. Lys9 of histone H3 is mono- or di-methylated by G9A/GLP and tri-methylated by SETDB1 to activate transcription. Tumor suppressor p53 is regulated by methylation of at least four sites. p53-mediated transcription is repressed following mono-methylation of p53 at Lys370 by SMYD2; Di-methylation at the same residue further inhibits p53 by preventing association with 53BP1. Concomitant di-methylation at Lys382 inhibits p53 ubiquitination following DNA damage. Di-methylation at Lys373 by G9A/GLP inhibits p53-mediated apoptosis and correlates with tri-methylation of histone H3 Lys9 at the p21 promoter.
- 應用類型
- WB, IHC, IF/ICC, IP
- 免疫原
- A synthetic peptide corresponding to a sequence containing dimethylatedK.
- 來源宿主
- Rabbit
- 反應性
- Human, Mouse, Rat, Other (Wide Range)
- 保存建議
- Store at 4
- 其他
- Bioworld是專一服務于生命科學研究的專業技術型企業，Bioworld品牌創立以來擁有10000多種常規產品現貨，現有8000多種現貨抗體，以及其他IVD原料，蛋白等現貨產品。在細胞信號通路、免疫學、蛋白組學上擁有顯著優勢，其抗體產品、生長因子、IVD原料等為生命科學科研工作者提供了極大的便利
- 注意
-
該頁面的中文產品信息的翻譯，僅供參考。準確的產品信息請以廠家的英文說明書為準。下單前，請瀏覽說明書確認。
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