POLR2F belongs to the archaeal rpoK/eukaryotic RPB6 RNA polymerase subunit family and is the sixth largest subunit of RNA polymerase II. This polymerase, along with two other DNA-directed RNA polymerases, is responsible for synthesizing messenger RNA in eukaryotes. Three distinct zinc-containing RNA polymerases are found in eukaryotic nuclei: polymerase I for the ribosomal RNA precursor, polymerase II for the mRNA precursor, and polymerase III for 5S and tRNA genes. Each class of RNA polymerase is assembled from 9 to 15 different polypeptides. In yeast, this polymerase subunit, in combination with at least two other subunits, forms a structure that stabilizes the transcribing polymerase on the DNA template.
