- 中文名稱
RAE1 polyclonal antibody
- 英文名字
- RAE1 polyclonal antibody
- 供應商
- Bioworld
- 產品貨號
- BS8377
- 產品報價
- ￥詢價/50ul
- 產品說明書
- 點擊查看
- 購買方式
- 銀行轉賬、電匯、支票、現金，在線支付寶及網銀支付，或直接與我們電話聯系400-6800-868
- 產品新聞
- 背景資料
- Natural killer (NK) cells attack tumor and infected cells, but the receptors andnligands that stimulate them are poorly understood. Two murine ligands fornthe lectin-like receptor NKG2D, H60 and retinoic acid early inducible (Rae-n1α, β, γ, δ and ε), are distant relatives of major histocompatibility complexnclass I molecules. These molecules are encoded by Rae-1 and H60 minornhistocompatibility antigen genes on mouse chromosome 10 and show weaknhomology with MHC class I. Expression of the NKG2D ligands is low or absentnon normal, adult tissues; however, they are constitutively expressed on somentumors and upregulated by retinoic acid. Ectopic expression of Rae-1 andnH60 confers target susceptibility to NK cell attack. NKG2D binds to H60 withnapproximately 25-fold higher affinity than to Rae-1. Rae-1 and H60 competendirectly for occupancy of NKG2D; therefore, NKG2D can be occupied by only one ligand at a time. Additionally, Rae-1 and H60 ligands of the NKG2Dnreceptor stimulate tumor immunity.
- 應用類型
- WB
- 免疫原
- Recombinant full length Human RAE1.
- 來源宿主
- Rabbit
- 反應性
- Human, Mouse, Rat
- 保存建議
- Store at 4
- 其他
- Bioworld是專一服務于生命科學研究的專業技術型企業，Bioworld品牌創立以來擁有10000多種常規產品現貨，現有8000多種現貨抗體，以及其他IVD原料，蛋白等現貨產品。在細胞信號通路、免疫學、蛋白組學上擁有顯著優勢，其抗體產品、生長因子、IVD原料等為生命科學科研工作者提供了極大的便利
- 注意
-
該頁面的中文產品信息的翻譯，僅供參考。準確的產品信息請以廠家的英文說明書為準。下單前，請瀏覽說明書確認。
-
