Akt, also referred to as PKB or Rac, plays a critical role in controlling survival and apoptosis. This protein kinase is activated by insulin and various growth and survival factors to function in a wortmannin-sensitive pathway involving PI3 kinase. Akt is activated by phospholipid binding and activation loop phosphorylation at Thr308 by PDK1 and by phosphorylation within the carboxy terminus at Ser473.
應用類型
ICC/IF,WB,IHC-F,IHC-P,ELISA
免疫原
The antiserum was produced against synthesized peptide derived from human AKT1/2/3. AA range:281-330
