Chemokine （C-X-C motif） ligand 10 （CXCL10） is a small cytokine belonging to the CXC chemokine family that is also known as 10 kDa interferon-gamma-induced protein （?-IP10 or IP-10）. CXCL10 is secreted by several cell types in response to IFN-?. These cell types include monocytes， endothelial cellsand fibroblasts. CXCL10 has been attributed to several roles， such as chemoattraction for monocytesand T cells， promotion of T cell adhesion to endothelial cells， anti tumor activity， and inhibition of bone marrow colony formation and angiogenesis. The gene for CXCL10 is located on human chromosome 4in a cluster among several other CXC chemokines. This chemokine elicits its effects by binding to the cell surface chemokine receptor CXCR3. The three-dimensional crystal structure of this chemokine has been determined under 3 different conditions to a resolution of up to 1.92A.
