TAFA-2 is a 11 kDa secreted protein that belongs to the FAM19/TAFA family of chemokine-like proteins. Similar to other FAM19/TAFA family members， mature TAFA-1 contains 10 regularly spaced cysteine residues with the same pattern: CX7CCX13CXCX14CX11CX4CX5CX10C （C symbolizes a conserved cysteine residue and X symbolizes any noncysteine amino acid）. Human TAFA-2 is 97% aa identical to mouse TAFA-2 and is expressed in the central nervous system （CNS）， colon， heart， lung， spleen， kidney， and thymus， however its expression in the CNS is 50 to 1000 fold higher than in other tissues. The biological roles of TAFA family members have not yet been determined.
