1-硬脂酰-2-花生四烯酸-sn-甘油是一種甘油二酯（DAG），其sn-1和sn-2位分別含有花生四烯酸和硬脂酸。1-硬脂酰-2-花生四烯酸-sn-甘油是一種甘油二酯，是PKC β ± PKC β μ和PKC β ′的有效激活劑，也與Ras激活劑RasGRP競爭性結合。1 2-二酰基甘油通過磷脂酶C水解磷脂酰肌醇4 5-二磷酸在細胞中形成。DAG激活蛋白激酶C（PKC），其是信號轉導細胞調節和腫瘤促進的關鍵調節劑。 加農B.R. &貝爾 （1985）“Exogenous sn-1 2-diacylglycerols Containing Saturated Fatty Acids Functions as Bioregulators of Protein Kinase C in Human Plastomy”J.Biol.Chem.260 1358- 1361. 盧米斯C.R. Hannun Y.A. &貝爾 （1986）“Specificity and Mechanism of Protein Kinase C Activation by sn-1 2-diacylglycerols”Proc.Natl. Acad. Sci.美國83 1184-1188.
產品描述
1-Stearoyl-2-arachidonoyl-sn-glycerol is a diacylglycerol (DAG) with polyunsaturated fatty acid arachidonic acid and stearic acid in the sn-1 and sn-2 positions respectively. 1-Stearoyl-2-arachidonoyl-sn-glycerol is a diacylglycerol is a potent activator of PKC?± PKC?μ and PKC?′ and also competitively binds to the Ras activator RasGRP. 1 2-Diacylglycerols are formed in cells through the hydrolysis of phosphatidylinositol 4 5-bisphosphate by Phospholipase C. DAGs activate Protein Kinase C (PKC) which is a key regulator of signal transduction cellular regulation and tumor promotion.References1) Lapetina E.G. Reep B. Ganong B.R. & Bell R.M. (1985) "Exogenous sn-1 2-diacylglycerols Containing Saturated Fatty Acids Functions as Bioregulators of Protein Kinase C in Human Platelets" J. Biol. Chem. 260 1358-1361.2) Ganong B.R. Loomis C.R. Hannun Y.A. & Bell R.M. (1986) "Specificity and Mechanism of Protein Kinase C Activation by sn-1 2-diacylglycerols" Proc. Natl. Acad. Sci. USA 83 1184-1188.
