I型腫瘤壞死因子受體(TNFRI)是一種55 kD的I型跨膜蛋白。TNFRI在多種細胞類型上以低水平獨立于TNFRII表達。TNFRI結合TNF-A和TNF-B(也稱為LT-A)。已知隨后的信號傳導對于誘導細胞溶解活性、抗病毒活性、錳超氧化物歧化酶和細胞間粘附分子(ICAM)的表達、IL-6 mRNA積累和NF-κ B誘導是重要的。TNFRI在其羧基末端附近攜帶大約80個氨基酸的死亡結構域,能夠通過其與TRADD(TNF受體I相關死亡結構域蛋白)的相互作用傳遞凋亡信號。已顯示55 R-170抗體與TNFRI的結合阻斷由配體結合引發的體外和體內受體信號傳導。 抗小鼠CD 120 a(55 R-593)體內抗體-低內毒素該產品同種型對照:Armenian Hamster IgG Isotype Control for In Vivo - Low Endotoxin [PIP] (ICH2251) 緩沖液:ICH3001-100ml,nICH3002-100ml,nICH3003-100ml, 濃度:1.0 mg/ml 純度:>95% by SDS-PAGE and HPLC 內毒素:≤ 1.0 EU/mg as determined by the LAL method 制劑:0.01 M phosphate buffered saline (PBS) pH 7.2, 150 mM NaCl with no carrier protein, potassium or preservatives added.
應用類型
Immunoprecipitation, Western Blot
免疫原
E. coli-expressed extracellular domain of the mouse TNFRI protein