當特異性地制備用于體內功能測定時，抗體在體外和體內阻斷I型IFN受體信號傳導，而不消耗攜帶IFNAR 1的細胞。該抗體通過用編碼鼠IFNAR1的胞外結構域的質粒對IFNAR1敲除小鼠進行體內遺傳免疫來產生。IFNAR1和IFNAR2在幾乎所有細胞上共表達，并構成結合所有I型IFN（IFN α和IFN β）的異二聚體受體。I型IFN是已經顯示在體內促進抗病毒、抗微生物、抗腫瘤和自身免疫應答的細胞因子家族。 抗小鼠IFNAR 1（MAR 1 - 5A 3）體內抗體-低內毒素該產品同種型對照：Mouse IgG1 Isotype Control for In Vivo - Low Endotoxin [HKSP] (ICH2247) 緩沖液：ICH3001-100ml，nICH3002-100ml，nICH3003-100ml， 濃度：≥ 2.0 mg/ml 純度：>95% by SDS-PAGE and HPLC 內毒素：≤ 1.0 EU/mg as determined by the LAL method 制劑：0.01 M phosphate buffered saline (PBS) pH 7.2 - 7.4, 150 mM NaCl with no carrier protein, potassium or preservatives added.
應用類型
Immunoprecipitation, Western Blot, Blocking, Functional Assays, Flow Cytometry, ELISA
免疫原
This antibody was produced by In vivo genetic immunization of IFNAR1 knockout mice with a plasmid encoding the extracellular domain of murine IFNAR1.
