CCR 5抗體HEK/1/85 a/7a識別C-C趨化因子受體5型(CCR 5),也稱為CD 195、CC-CKR-5、CHEMR 13和HIV-1融合輔助受體。CCR 5是一種45 kDa的七跨膜G蛋白偶聯受體(GPCR)。CCR 5在記憶T細胞、巨噬細胞和未成熟樹突狀細胞(DC)的亞群上表達,并被促炎細胞因子上調。CCR 5與炎性CC-趨化因子結合,包括CCL 3(巨噬細胞炎性蛋白(MIP)-1α)、CCL 4(MIP-1β)和RANTES,其增加細胞內鈣水平并導致細胞骨架重排和趨化細胞遷移。CCR 5也是HIV-1的輔助受體,在病毒gp 120與CD 44 -7結合后。細胞上CCR 5的水平影響HIV-1的進入率,CCR 5水平較低的患者表現出抗感染的免疫力。CCR 5還導致其他人類疾病,包括I型糖尿病和癌癥。 Bulk Anti-Human CD 195(HEK/1/85 a/7a)Antibody(CCR 5)-超低內毒素該產品同種型對照:Rat IgG2b In Vivo Isotype Control - Low Endotoxin [1-2] (ICH2243) 緩沖液:ICH3001-100ml,nICH3002-100ml,nICH3003-100ml, 濃度:≥ 5.0 mg/ml 純度:>98% by SDS-PAGE and HPLC 內毒素:≤ 0.5 EU/mg as determined by the LAL method 制劑:This monoclonal antibody is aseptically packaged and formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.2 - 7.4 with no carrier protein, potassium, calcium or preservatives added.
應用類型
Flow Cytometry, ImmunoCytochemistry
免疫原
CHO cells transfected with full-length human CD195 (CCR5).