Lens fiber major intrinsic protein also called MIP26 or MP26 is a protein that in humans is encoded by the MIP gene. MIP is a member of the water-transporting aquaporins as well as the original member of the MIP family of channel proteins. Using 2-color fluorescence in situ hybridization on high-resolution R-banded chromosomes and human genomic DNA clones for MIP as probes, this gene was found that located in close proximity in region 12q13. MIP plays a crucial role in the development of a transparent eye lens. This gene may be responsible for regulating the osmolarity of the lens and interactions between homotetramers from adjoining membranes may stabilize cell junctions in the eye lens core.
應用類型
WB
免疫原
A synthetic peptide corresponding to a sequence at the C-terminus of mouse Aquaporin 0(246-263aa NGQPEGTGEPVELKTQAL), identical to the related rat sequence, and different from the related human sequence by two amino acids.
