Acts as a negative regulator of the proliferation of normal cells by interacting strongly with CDK4 and CDK6. This inhibits their ability to interact with cyclins D and to phosphorylate the retinoblastoma protein. This activity has the effect of suppressing tumor formation and growth, and of inducing replicative senescence in various normal cells, including stem cells. The expression of Cyclin-Dependent Kinase Inhibitor 2A steadily increases with age, and tends to accumulate in stem cell compartments. The deletion, rearrangement, or mutation of the Cyclin-Dependent Kinase Inhibitor 2A gene is frequently found in melanomas, as well as in certain other types of cancer.
序列
提供的細胞周期蛋白依賴性激酶抑制劑2A，人類重組Cyclin-dependent kinase inhibitor 2A, Human Recombinant是Biovision品牌中國區域總代理艾美捷科技產品，具體的蛋白序列可查看提供的英文版本產品說明書。
來源宿主
提供的細胞周期蛋白依賴性激酶抑制劑2A，人類重組Cyclin-dependent kinase inhibitor 2A, Human Recombinant產品來源宿主，查看該產品說明書，或者在線咨詢我們。
溶解建議
Reconstitute in sterile PBS (pH 8.0) to a concentration of 0.1-1.0 mg/ml. Do not vortex. Additional carrier protein (example 0.1% BSA) is recommended for long term storage.
