Inosine monophosphate dehydrogenase, IMPDH, (E.C. 1.1.1.205) is the rate-limiting enzyme in de novo guanine nucleotide biosynthesis and it is essential for lymphocyte proliferation. IMPDH oxidizes inosine 5’-monophosphate (IMP) to xanthine 5’-monophosphate (XMP) using NAD as a cofactor. It plays a critical role in cell growth and in the malignancy of some tumors. IMPDH II is the predominant isoform of IMPDH and is specifically linked to a wide range of cancers and lymphocyte proliferation. BioVision’s active human IMPDH II is suitable for functional assays, high-throughput screening and preclinical studies in drug discovery.
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提供的人重組肌苷5'-單磷酸脫氫酶IIHuman Inosine-5′-Monophosphate Dehydrogenase II, human recombinant是Biovision品牌中國區域總代理艾美捷科技產品,具體的蛋白序列可查看提供的英文版本產品說明書。
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