Hemopexin (HPX) is plasma glycoprotein belongs to the family of the acute-phase proteins whose synthesis is induced after an inflammatory event. Hemopexin with two four-bladed beta -propeller folds has been found in other proteins including collagenases and provides sites for protein-protein interactions. The liver is the major synthesizing organ. Hemopexin participates in maintaining and recycling the iron pool by utilizing its high binding affinity toward heme composed of protoporphyrin IX and iron. It also functions in preventing oxidation caused by heme after hemolysis. Hydrophobic heme molecules can intercalate into lipid membranes and participate in the oxidation of lipid membrane components through the Fenton reaction resulting in lipid peroxidation. Hemopexin undergoes a conformational change upon the binding of heme. The conformational change allows hemopexin to interact with a specific receptor, forming a complex which is then internalized. Heme concentrations in plasma increase after hemolysis, which is associated with several pathological conditions such as reperfusion injury and ischemia.
序列
提供的Human CellExp?血凝素，人類重組Human CellExp? Hemopexin, Human Recombinant是Biovision品牌中國區域總代理艾美捷科技產品，具體的蛋白序列可查看提供的英文版本產品說明書。
來源宿主
提供的Human CellExp?血凝素，人類重組Human CellExp? Hemopexin, Human Recombinant產品來源宿主，查看該產品說明書，或者在線咨詢我們。
溶解建議
該Human CellExp?血凝素，人類重組Human CellExp? Hemopexin, Human Recombinant產品的溶解建議詳情請查閱產品說明書。
