T-cell immunoreceptor with Ig and ITIM domains (TIGIT) is also known as V-set and immunoglobulin domain-containing protein 9 (VSIG9), V-set and transmembrane domain-containing protein 3 (VSTM3), which belongs to single-pass type I membrane protein containing an immunoglobulin variable domain, a transmembrane domain and an immunoreceptor tyrosine-based inhibitory motif (ITIM). TIGIT is expressed at low levels on peripheral memory and regulatory CD4+ T-cells and NK cells and is up-regulated following activation of these cells (at protein level). TIGIT binds with high affinity to the poliovirus receptor (PVR) which causes increased secretion of IL10 and decreased secretion of IL12B and suppresses T-cell activation by promoting the generation of mature immunoregulatory dendritic cells.
序列
提供的Human CellExp?TIGIT，Fc標簽，小鼠重組Human CellExp? TIGIT, Fc Tag, Mouse Recombinant是Biovision品牌中國區域總代理艾美捷科技產品，具體的蛋白序列可查看提供的英文版本產品說明書。
來源宿主
提供的Human CellExp?TIGIT，Fc標簽，小鼠重組Human CellExp? TIGIT, Fc Tag, Mouse Recombinant產品來源宿主，查看該產品說明書，或者在線咨詢我們。
溶解建議
Reconstitute in sterile deionized water to the desired protein concentration.
